Promoting intrinsic axon regenerative ability by blocking TGF-Beta activity
Funded in: 2008, 2009, 2010
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The aim is to test the hypothesis that members of the TGF-beta protein family act as a negative signal in regulating intrinsic axonal growth ability of lesioned nerve fibers. This negative effect may be one of the mechanisms that prevent axonal regeneration following spinal cord injury. If this holds true, block of particular TGF-beta protein family members might become a potential therapeutic strategy for regenerative treatments.