Mark Kotter, Medical University Vienna, Vienna, Austria

Overcoming the myelin mediated inhibition of remyelination by elevation of CAMP

Funded in: 2007, 2008, 2009

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Myelin is the insulation sheath around nerve fibres. If this protective layer is injured, the affected nerves are no longer functional. The adult brain contains special cells (OPCs) that are in theory capable to replace the destroyed myelin but fail to do so. One reason seems to be that the factors that are inhibiting the nerve regeneration are also inhibiting the myelin regeneration. This study will test the capacity of treatment that are know to promote the neuron regeneration to promote the myelin regeneration.