Yoshio Takashima, University of California, San Diego, USA

Neural modulation to enhance functional recovery

Funded in: 2020, 2021, 2022


Back to overview

Problem: No therapeutic treatment interventions available
Target: Combine neural stem cell transplantation, cortical epidural electrical stimulation and physical rehabilitation
Goal: Unlock the nature of regeneration and ultimately aid in recovery process

To date, there is no adequate treatment proven effective in ameliorating the repercussions involved in this type of trauma. Spinal cord injury (SCI) is a life-changing condition, which affects not only those who are suffering from the SCI, but also surrounding people physically, emotionally, and socio-economically. Thus, there is an urgent need for the development of therapeutic treatment interventions. In this study, neural stem cell technology will be combined with cutting edge neuroscience techniques to identify underlying fundamental biological mechanism involved in functional recovery after SCI.  For the first time, this research group will examine whether a novel combinatorial treatments paradigm of neural stem cell transplantation, cortical epidural electrical stimulation, and physical rehabilitation can promote further improvement in functional recovery after SCI. They will employ anatomy, Calcium imaging and electrophysiology to characterize the recovery mechanism. Thus, this study will lead to a new insight that could help the field of SCI move one step closer to unlocking the nature of regeneration and ultimately aid in recovery process. The knowledge gained by understanding the fundamental biological mechanism involved in functional recovery will further advance spinal cord repair after injury. The researchers hope to improve the quality of life in people suffering from SCI.