Wolfram Tetzlaff / Brian Kwon, ICORD, Vancouver, Canada

Combination of minocyline and simvastatin to protect spinal cord after injury

Funded in: 2006, 2007, 2008, 2009

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Some pharmaceutical drugs which were originally developed to treat various types of diseases also demonstrate positive effects in the case of neurological disorders. Previous work from this team showed that two of these medications (simvastatin and minocycline) reduce subsequent damage in spinal cord injuries. This new project will test whether these two drugs will have an additive effect when combined. Longer treatments will be also tested since simvastatin has been suggested not only to have a neuroprotective effect but also to promote axonal regeneration. The effect is studied by testing neurological function (leg muscle control), secondary damage and through additional, detailed anatomical changes in the lesioned spinal cord.