Publications 2013: Part 2

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30 research projects were published in 2013. The publications show the advancements done in all research fields related to spinal cord injury.

Close collaboration between the scientists and the discussion of their results are essential for optimal research progress. To share their results, scientists publish their work in special interest journals. Please find below the latest publications of research projects that have been funded by Wings for Life, sorted by their key area of research.

Secondary damage (protection of intact cells)
These findings based on multiple sclerosis give new hints on neuroinflammation resolution that is associated with secondary damage in spinal cord injury.

  • Prüss H, Rosche B, Sullivan AB, Brommer B, Wengert O, Gronert K, Schwab JM. Proresolution lipid mediators in multiple sclerosis - differential, disease severity-dependent synthesis - a clinical pilot trial. PLoS One.

Plasticity (eliminating growth inhibitors)
The following publication gives insights in the complex matrix that is found between the cells, exactly where neurons are supposed to regenerate and get the maximum regrowth inhibition.

  • Dick G, Tan CL, Alves JN, Ehlert EM, Miller GM, Hsieh-Wilson LC, Sugahara K, Oosterhof A, van Kuppevelt TH, Verhaagen J, Fawcett JW, Kwok JC Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E Motifs in Rodent Brains. J Biol Chem.

Regeneration (nerve growth)
While the first two publications explore the importance of intracellular signaling to promote neuronal regeneration, the publication of Dr. Oudega tests a new kind of biomaterial to be transplanted at the injury site. Dr. Strittmatter demonstrated that a particular electrical stimulation, associated with exercise could promote functional restoration. The article of Dr. Fainzilber proved the importance of intracellular local protein synthesis for developing and regenerating axons. Finally, the last two publications (Dr. Fouad and Dr. Olson) explored the effect of combinatorial treatments for promoting nerve growth.

  • Tedeschi A, Bradke F. The DLK signalling pathway--a double-edged sword in neural development and regeneration. EMBO Rep.
  • Shin JE, Geisler S, Diantonio A. Dynamic regulation of SCG10 in regenerating axons after injury. Exp Neurol.
  • Haggerty AE, Oudega M. Biomaterials for spinal cord repair. Neurosci Bull
  • Harel NY, Yigitkanli K, Fu Y, Cafferty WB, Strittmatter SM. Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion. Brain Res.
  • Perry RB, Fainzilber M. Local translation in neuronal processes-in vivo tests of a "heretical hypothesis" Dev Neurobiol.
  • Fouad K, Bennett DJ, Vavrek R, Blesch A. Long-term viral brain-derived neurotrophic factor delivery promotes spasticity in rats with a cervical spinal cord hemisection. Front Neurol.
  • Olson L. Combinatory treatments needed for spinal cord injury. Exp Neurol.

Neural reconstruction (introduction of new cells)
The group of Dr. Fehlings found a way to increase the clinical potential of induced pluripotent stem cells (iPSCs), a category of stem cells that may solve many issues common to cell based therapy strategies like immune response and cell availability. The last two publications focus on the effect of stem cell grafting on functional recovery and on the interaction of stem cells with the inflammatory tissue reaction.

  • Salewski RP, Buttigieg J, Mitchell RA, van der Kooy D, Nagy A, Fehlings MG. The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway. Stem Cells Dev.
  • Hou S, Tom VJ, Graham L, Lu P, Blesch A. Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection J Neurosci
  • Pluchino S, Cossetti C. How stem cells speak with host immune cells in inflammatory brain diseases. Glia.

Remyelination (insulation of nerve fibres)
This article from the team of Dr. Barnett proves that only a particular subpopulation of mesenchymal stem cells is able to restore myelination of neurons.

  • Lindsay SL, Johnstone SA, Mountford JC, Sheikh S, Allan DB, Clark L, Barnett SC. Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelination in vitro. Glia.

The first publication proves that the usage of imaging techniques as outcome predictive tool can be successfully achieved. The two publications in Neuroimage finally give an overview of the advancements of spinal cord imaging.

  • Yuh EL, Mukherjee P, Lingsma HF, Yue JK, Ferguson AR, Gordon WA, Valadka AB, Schnyer DM, Okonkwo DO, Maas AI, Manley GT; TRACK-TBI Investigators. Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury. Ann Neurol.
  • Stroman PW, Wheeler-Kingshott C, Bacon M, Schwab JM, Bosma R, Brooks J, Cadotte D, Carlstedt T, Ciccarelli O, Cohen-Adad J, Curt A, Evangelou N, Fehlings MG, Filippi M, Kelley BJ, Kollias S, Mackay A, Porro CA, Smith S, Strittmatter SM, Summers P, Tracey I. The current state-of-the-art of spinal cord imaging: Methods. Neuroimage.
  • Wheeler-Kingshott CA, Stroman PW, Schwab JM, Bacon M, Bosma R, Brooks J, Cadotte DW, Carlstedt T, Ciccarelli O, Cohen-Adad J, Curt A, Evangelou N, Fehlings MG, Filippi M, Kelley BJ, Kollias S, Mackay A, Porro CA, Smith S, Strittmatter SM, Summers P, Thompson AJ, Tracey I. The current state-of-the-art of spinal cord imaging: Applications. Neuroimage.

Compensation treatment
The following eleven publications can be divided in three categories. Most articles are reporting the benefits of particular rehabilitation techniques (electrical stimulation, etc.) on human locomotor activity. The second category explores the effect of immune disturbance on functional recovery, while the last three articles discuss of the importance of experimental models in fundamental research.

  • Hofstoetter US, Hofer C, Kern H, Danner SM, Mayr W, Dimitrijevic MR, Minassian K. Effects of transcutaneous spinal cord stimulation on voluntary locomotor activity in an incomplete spinal cord injured individual. Biomed Tech (Berl).
  • Minassian K, Hofstoetter US, Danner SM, Mayr W, McKay WB, Tansey K, Dimitrijevic MR. Mechanisms of rhythm generation of the human lumbar spinal cord in response to tonic stimulation without and with step-related sensory feedback. Biomed Tech (Berl).
  • Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR, Minassian K. Pattern Generating Networks in the Human Lumbar Spinal Cord: Electrophysiology and Computer Modeling. Biomed Tech (Berl).
  • Krenn M, Toth A, Danner SM, Hofstoetter US, Minassian K, Mayr W. Selectivity of transcutaneous stimulation of lumbar posterior roots at different spinal levels in humans. Biomed Tech (Berl).
  • Dimitrijevic MR. The conducting and processing capabilities of the human lumbar cord network and "spinal brain". Biomed Tech (Berl).
  • Hubli M, Dietz V, Schrafl-Altermatt M, Bolliger M. Modulation of spinal neuronal excitability by spinal direct currents and locomotion after spinal cord injury. Clin Neurophysiol.
  • Hubli M, Dietz V. The physiological basis of neurorehabilitation--locomotor training after spinal cord injury. J Neuroeng Rehabil.
  • Kopp MA, Druschel C, Meisel C, Liebscher T, Prilipp E, Watzlawick R, Cinelli P, Niedeggen A, Schaser KD, Wanner GA, Curt A, Lindemann G, Nugaeva N, Fehlings MG, Vajkoczy P, Cabraja M, Dengler J, Ertel W, Ekkernkamp A, Martus P, Volk HD, Unterwalder N, Kölsch U, Brommer B, Hellmann RC, Ossami Saidi RR, Laginha I, Prüss H, Failli V, Dirnagl U, Schwab JM. The SCIentinel study - prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS) - study protocol and interim feasibility data. BMC Neurol.
  • Hurd C, Weishaupt N, Fouad K. Anatomical correlates of recovery in single pellet reaching in spinal cord injured rats. Exp Neurol.
  • Hilton BJ, Assinck P, Duncan GJ, Lu D, Lo S, Tetzlaff W Dorsolateral funiculus lesioning of the mouse cervical spinal cord at C4 but not at C6 results in sustained forelimb motor deficits. J Neurotrauma.
  • Kjell J, Sandor K, Josephson A, Svensson CI, Abrams MB. Rat substrains differ in the magnitude of spontaneous locomotor recovery and in the development of mechanical hypersensitivity after experimental spinal cord injury. J Neurotrauma.

By its content the following article belongs to a particular category. The research of Dr. Ferguson has an application on all fields related to spinal cord injury. This in silico analysis of preclinical outcome data from 10 years of basic research on spinal cord injury gave outstanding results which will have, on the long run, a strong impact on the whole spinal cord injury field. Their particular approach provides indeed a roadmap for translating therapies from basic to clinical research.

  • Ferguson AR, Irvine KA, Gensel JC, Nielson JL, Lin A, Ly J, Segal MR, Ratan RR, Bresnahan JC, Beattie MS. Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PLoS One.