Brain Res Brain Res Rev, Sep 2005

Injury reactive myelin/oligodendrocyte-derived axon growth inhibition in the adult mammalian central nervous system.

Schwab JM, Bernard F, Moreau-Fauvarque C, Chédotal A.



Myelin inhibition is considered a constitutive, static, repulsive barrier not reactive to a central nervous system (CNS) lesion. However, recent evidence underlines the existence of considerable add-on axon growth inhibition upon CNS injury. This postlesional, reactive myelin/oligodendrocyte-derived inhibition will require the development of novel screening approaches and therapeutic reagents to promote axonal regeneration.


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