Simone DiGiovanni, Hertie Institut für Klinische Hirnforschung, Tübingen, Germany

Role of pro-axonal genes in regeneration

Funded in: 2010, 2011

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Adult motoneurons are intrinsically deficient in the expression of genes functionally involved in axonal outgrowth resulting in a limited intrinsic sprouting and regenerative potential. Aim of the project is to induce axon sprouting and regeneration in motoneurons through the activation of a specific transcriptions program of pro-axonal genes regulated by p53, resulting in a better functional recovery.