Maria Teresa Viscomi, Santa Lucia Foundation, Rome, Italy

Role of endocannabinoid signalling in remote damage after spinal cord injury

Funded in: 2011, 2012

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Spinal cord injury (SCI) is a devastating condition of the central nervous system (CNS) often resulting in severe functional impairment As in other CNS injuries, beside the effects related to the primary site of damage, functional impairment after SCI is highly dependent from degeneration that occurs in regions that are remote, but functionally connected, to the primary lesion site.

This project will explore new therapeutic approaches promoting rescue of axotomized neurons and stimulating regeneration of spinal tracts through the modulation of endocannabinoids system.
The present project we will analyze the influence of pharmacological/genetic modulation/ablation of the endocannabinoid system on

  • neuronal survival
  • axonal regeneration
  • reorganization of the spinal tracts and neurological recovery after spinal cord hemisection
  • This study will provide the opening of a new approach for the exploitation of neuroprotective drugs.