Neuroprotection and regeneration in the spinal cord via the modulation of the prostaglandin pathway
Funded in: 2007, 2008, 2009
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Secondary tissue damage that occurs after spinal cord injury contributes significantly to permanent functional disabilities. Preventing or minimizing such secondary damage can be expected to substantially reduce the functional disability that occurs after SCI. Inflammation is thought to contribute importantly to this damage and there are specific molecules (prostaglandins) that either boost or diminish its amplitude. The aim of this project is to understand which of these molecules (prostaglandin/receptor interactions) are involved in those two opposite effects. In the end obtaining a selective blocking of the damaging immune response and a boosting of the protective immune response will correspond to improved functional outcomes after spinal cord injury.