Friedrich Propst, University Vienna, Vienna, Austria

Effect of inflammatory cells

Funded in: 2007, 2008, 2009

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Results of current research show that nitric oxides are released as a result of inflammations in spinal cord injuries. These impact the protein MAP1B in the injured nerve fibres (nitrosylation) and then cause their degeneration. It is still not known whether or not nitric oxide also act in consequence of other growth inhibiting proteins. This research project studies whether nitrosylation as a biochemical pathway is a general feature of nerve growth blockade. If so, nitrosylation (as a biochemical pathway) could be a target to prevent nerve growth blockade. This knowledge is fundamental for the successful bridging of spinal cord injuries.