Zhigang He, Children's Hospital Harvard Medical School, Boston, USA

Blocking two signalling pathways triggered by growth inhibitors (PKC Decrease and camp increase)

Funded in: 2006, 2007, 2008

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After injury, protein kinase C (PKC) is generated inside the damaged nerve fibre which leads to degeneration of nerve fibres and prevents the formation of new connections. Thus PKC inhibitors are supposed to stimulate nerve growth in the injured spinal cord. In addition, the raise of cAMP level (another important cascade) should promote nerve fibre growth. Modulation of two important signalling pathways together may result in a more robust regeneration.