© Ting Yu
Ting Yu, University of California, Division of Biology, Section of Neuroscience, San Diego, USA

Wnt/planar cell polarity signaling in astroglial response in spinal cord injury

Funded in: 2017, 2018, 2019


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Problem: The details of astrocyte reactivation after spinal cord injury are unknown.

Target: Explore the role of planar cell polarity pathway in controlling astrocyte response and scar formation following injury

Goal: A better understanding of this mechanism would help developing therapeutic strategies for axon regeneration after spinal cord injury

 

In response to damage from spinal cord injury, astrocytes become reactivated and constitute one of the principal components of glial scar. How astrocyte reactivation is initiated and what cellular signaling pathways are involved in astrocyte polarization is unknown. The research object of this study is to explore the role of a signaling pathway called planar cell polarity pathway in controlling astrocyte response and scar formation following injury. Models of spinal cord injury combined with genetic approaches will be applied in the study. A better understanding of the cellular signaling mechanism underlying reactive astrocyte response and scar formation following injury would be an important piece of information for developing therapeutic strategies for axon regeneration after spinal cord injury.