What is the contribution of the different cell types of the olfactory mucosa for the therapeutic repair potential in spinal cord injury?
Funded in: 2010, 2011, 2012
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The project is about to
- find the optimal mixture of different cells from the olfactory mucosa for successful repair in spinal cord injury,
- characterize the different cell types of the lamina mucosa and their interactions in vitro and
- investigate their repair potential in an experimental model for spinal cord injury.
Tissue from olfactory mucosa is considered as a potential source of stem cells and myelinating cells, which can be used for therapeutic strategies in spinal cord injury.
Aim of this basic science project is
- to explore the biological characteristics of cells of the olfactory mucosa
- to determine the effect on axonal growing and myelination in vitro
- to determine the therapeutic potential of human olfactory cells for spinal cord injury in an experimental model for spinal cord injury
