Remyelination of regenerated axons for electrophysiological and functional recovery
Funded in: 2011, 2012
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In previous studies was demonstrated that chemotropic guidance allows for ascending sensory axons to bridge for short distances across a lesion site and that the distance of sensory axon regeneration can be increased when gradients of neurotrophic factors are combined with stimulation of regenerative responses at the cell soma.
Despite the formation of identified synapses, regenerated axons were not electrophysiologically active to support functional recovery. Regenerated axons were found to lack appropriate remyelination.
The proposed studies therefore aim to remyelinate regenerating axons by the transplantation of a mixture of BMSC and adult NPC.
The aims of the project are:
- to investigate whether a mixture of BMSC and adult NPC will induce axonal bridging, target reinnervation and remyelination of regenerating dorsal column sensory axons
- to investigate the influences of BMP neutralization on oligodendrogenic differentiation