Abdeljabbar El Manira / Ole Kiehn, Karolinska Institute, Stockholm, Sweden

Organization and plasticity of spinal cord networks controlling locomotion

Funded in: 2007, 2008, 2009


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Special neural circuits in the spinal cord, called central pattern generators (CPGs), can produce automatic movements. These circuits have a highly specific and complex structure that is altered after a spinal cord injury. In order to restore motor function after paralysis we need to exactly understand how the healthy spinal cord produces movements and what changes occur within the spinal circuitry following injury.