Fundamental research and clinical studies

Funded projects

Manipulation of the local translation of Rho GTPases in axons to support axon regeneration

Priyanka Patel, University of South Carolina, Biological Sciences Manipulation of the local translation of Rho GTPases in axons to support axon regeneration

Modulation of C1q receptor signalling in NSC to rescue regenerative potential in the SCI niche

Aileen Anderson, The Regents of the University of California Modulation of C1q receptor signalling in NSC to rescue regenerative potential in the SCI niche

Wolfram Tetzlaff, University of British Columbia, ICORD

Role of remyelination in recovery after spinal cord injury

Modulating the extracellular matrix to induce axon regrowth and recovery after spinal cord injury

Heikki Rauvala, HiLIFE (Helsinki Institute of Life Science)/Neuroscience Center; University of Helsinki Modulating the extracellular matrix to induce axon regrowth and recovery after spinal cord injury

Stimulation and support of propriospinal axon regeneration across chronic anatomically complete SCI

Michael Sofroniew, University of California Los Angeles, Department of Neurobiology Stimulation and support of propriospinal axon regeneration across chronic anatomically complete SCI

Brain-controlled spinal cord stimulation to alleviate gait deficits in people with paraplegia

Tomislav Milekovic, University of Geneva, Department of Fundamental Neuroscience Brain-controlled spinal cord stimulation to alleviate gait deficits in people with paraplegia

Abdominal Functional Electrical Stimulation To Reduce Respiratory Complications in Spinal Cord Injury

Bonsan Bonne Lee, Prince of Wales Hospital and Neuroscience Research Australia Abdominal Functional Electrical Stimulation To Reduce Respiratory Complications in Spinal Cord Injury

Discovering blood RNA biomarkers for diagnosis of SCI severity and/or prognosis of neurological recovery

Nikolaos Kyritsis, Brain and Spinal Injury Center, University of California San Francisco Discovering blood RNA biomarkers for diagnosis of SCI severity and/or prognosis of neurological recovery

Blood Biomarkers to Predict Outcome after Spinal Cord Injury: A Precision-Medicine Approach

Catherine Jutzeler und John Kramer, ICORD, University of British Columbia Blood Biomarkers to Predict Outcome after Spinal Cord Injury: A Precision-Medicine Approach

Transcriptomic Screen to Identify New Genetic Pathways and Strategies to Promote Axon Regeneration after SCI

Anne Jacobi, F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School, Harvard University Transcriptomic Screen to Identify New Genetic Pathways and Strategies to Promote Axon Regeneration after SCI

Many ways to achieve our goal

Key areas of research

Secondary damage (protection of intact cells)
A spinal cord injury is followed by a massive breakdown of neuronal and supporting cells (known as glial cells) around the site of injury. This area of research aims to prevent the secondary damage and therefore preserve more functions for those affected.

Plasticity
Spinal cord injury is accompanied by the release of substances that block the renewed growth of nerves. The aim is to find, analyse and eliminate these substances known as natural growth inhibitors. In the last few years major advancements have been made in this area of research. Additionally it is important to understand the mechanisms underlying the reorganization of the spinal circuitry and interconnections.

Regeneration
When an adult nerve fibre in the central nervous system is completely severed, its ability to regrow is very restricted. Wings for Life funds projects that searching for ways to stimulate nerves to regenerate and regrow.

Neural reconstruction
This area of research aims to replace destroyed tissue by the transplantation of cells and/or biomaterials. Very promising approaches focus on the use of stem cells or prosthetic biomaterials to repair injured spinal cord tissue.

Remyelination (insulation of nerve fibres)
Injured nerve fibres lose their protective cover, known as the myelin sheath. Like an electric wire that loses its insulation, the demyelinated nerve fibres lose their ability to properly transmit signals. Wings for Life supports research that aims to restore this protective sheath (remyelination) and to improve nerve cell function.

Imaging
A number of preclinical studies report positive results, like enhanced growth of nerve fibres and a better behavioral outcome. However, we currently lack imaging techniques to monitor the changes in the spinal cord tissue in vivo. This fact makes it difficult to elucidate the underlying mechanisms and to compare the results. Wings for Life is doing pioneering work in this field by funding studies aiming to develop better in vivo imaging techniques.

Rehabilitation/Compensatory treatment
Research projects in this area are not focused on direct restoration of the injured nervous system, but on the improvement of the functional deficits and thus improving the affected individual's quality of life. In this field, Wings for Life funds projects aimed at restoring bladder function and the treatment of neuropathic pain, and at developing new rehabilitation methods, to name but a few examples.

Wings for Life

Glossary

Please find explanations to technical terms in our glossary.

Calendar of events

Scientific Meetings

Researchers exchange their knowledge through meetings and conferences. You can find a list of all scientific meetings here.

Scientific knowledge

Progress is being made

 

In the last few years Wings for Life has been able to initiate a large number of promising projects, especially in the fields of basic and preclinical research. The next major step will be to translate these into clinical studies that ultimately lead to treatments for spinal cord injury.

Due to the complex nature of paralysis, a combination of various therapeutic approaches seems to offer the best chances of success. Major approaches currently under development include:

Reducing secondary damage
An advanced area of research relates to treatment options for patients in the early stages after a spinal cord injury. Several pharmacological interventions are currently tested in clinical phase I/II studies, for example Riluzole or Minocycline. These pharmacological therapeutics are reported to reduce additional tissue damage resulting in a better functional recovery of the patients. A recently published study with Minocycline performed at the University of Calgary showed a better outcome in motor functions.

Eliminating growth inhibitors
After a spinal cord injury, there is a lot of cell debris in the spinal tissue which can significantly limit the regeneration of nerves. Various types of cell debris send signals to nerve fibres saying: “Stop. This is a dead end.” For example, one of the stop signs responsible is known to be the protein Nogo. A substance to counteract the effect of Nogo is already being tested in a clinical study for patients in the early stages after a spinal cord injury (Prof. Dr. Martin Schwab, Nogo antibody study by Novartis). In a model for those living with a spinal cord injury as an ongoing condition, Prof. Dr. Stephen M. Strittmatter and his research team have succeeded in blocking several of these stop signs simultaneously and as a result saw marked functional improvements.


Axon growth
Nerve cells in the central nervous system lose most of their ability to regenerate as they mature. Therefore, researchers focus on “switches” that would overcome this challenge. For example, the research group working with Zhigang He at the Children’s Hospital in Harvard has identified that it is possible to trigger the regeneration of axons to a previously unknown extent by eliminating two molecular stop signs within the nerve cell (PTEN and SOCS3).

Cell-based approaches
Based on successful preclinical projects, there is a lot of hope surrounding therapies with stem cells as these are able to form tissue scaffolds, release growth factors, form new circuits and promote the regrowth of the protective myelin sheath. There are still important questions surrounding which cells are compatible for transplantation into the injured spinal cord. Answers to these questions are being sought through a first European clinical study (phase I/II) using neural human precursor/stem cells at the University Clinic Balgrist under the direction of Prof. Dr. Armin Curt.

These examples of scientific results and developments provide strong hope that treatment options are closer than they have ever been. However, intensive research work will be needed before a breakthrough in human medicine can be achieved.

The best seal of approval

Reviewers

Leading scientists carry out a peer review process in order to select the most promising research projects. The following list names the scientists and clinicians who evaluated the projects that were submitted to Wings for Life in the past.

These highly reputable researchers and opinion leaders in their respective fields have helped to ensure optimal investment of Wings for Life funding in research. Their knowledge is essential for an independent and transparent selection of outstanding projects.

Publications

Researchers share their findings